Clinical Grade Bioactivity Olive Oils – Extremely High D1 Index Extra Virgin Olive Oils with Exceptional Anti-Inflammatory Potential (D1: 2000+ mg/kg)

This category contains some of the most bioactive extra virgin olive oils available, with a D1 Index above 2000 mg/kg.

The D1 Bioactivity Index reflects the concentration of oleocanthal and oleacein and is considered one of the most advanced indicators of the anti-inflammatory potential and biological activity of extra virgin olive oil.

What is the D1 Bioactivity Index?

The D1 Bioactivity Index represents the combined concentration of oleocanthal and oleacein — the two most important anti-inflammatory phenolic compounds naturally present in extra virgin olive oil.

Unlike standard “total polyphenol” values, the D1 Index focuses specifically on the phenolic compounds most closely associated with the characteristic peppery sensation, anti-inflammatory activity and biological functionality of premium EVOO.

The D1 value is included in every NMR laboratory analysis available for our high phenolic olive oils.

D1 Index vs EU Health Claim 432/2012

The European Health Claim EU 432/2012 is based on the total concentration of hydroxytyrosol and its derivatives and requires a minimum of 250 mg/kg polyphenols for the approved health claim related to protection of blood lipids from oxidative stress.

The D1 Bioactivity Index is a separate parameter and is not part of the official EU health claim regulation. Instead, it is used as an advanced indicator of olive oil bioactivity and anti-inflammatory potential.